How We Improve Transdermal Drug Delivery Systems (TDDS) and Their Efficacy 

Transdermal administration delivers medication through the skin via patches or other delivery systems.

They...

Avoid the first-pass effect of metabolism associated with the oral route and allows for improved bioavailability.

Prolong release of certain medications, which can improve patient adherence.

Minimize adverse effects due to lower drug peak concentrations.

THE DERMATOLOGY MARKET
$12.7 Billion
2017 Market Size
5.4% CAGR
2017-2020
$16.7 Billion
2020 Market Size Estimate
Global Transdermal Delivery  Market Forecast
(In Billions of USD, LTS Gruppe, 2018)

Patches and gels are the two most prevalent TDDS for API while sprays and creams are more prevalent for OTC therapies. The most widely used APIs for TDDS are:

 

The Issues with Transdermal Patches and Delivery of Active Pharmaceutical Agents (APIs)

1st Generation Patches Have Limitations in API Delivery and Efficacy

Weak skin penetration

     Crystalline APIs

     High Layer Thickness

     Applications to large skin surface area

Low Cosmetic Acceptability
Cross Contamination
Skin Irritation
High Ecological Burden

There is a significant loss of pharmaceutical therapies 

API Penetration and Retention Rates of API's are Low